A genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta - cell function over five years of follow - up
نویسندگان
چکیده
Ehm A Andersson, Kristine H Allin, Camilla H Sandholt, Anders Borglykke, Cathrine J Lau, Rasmus Ribel-Madsen, Thomas Sparsø, Johanne M Justesen, Marie N Harder, Marit E Jørgensen, Torben Jørgensen, Torben Hansen and Oluf Pedersen The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark. Steno Diabetes Center A/S, Gentofte, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Faculty of Medicine, Aalborg University Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark.
منابع مشابه
Genetic Risk Score of 46 Type 2 Diabetes Risk Variants Associates With Changes in Plasma Glucose and Estimates of Pancreatic β-Cell Function Over 5 Years of Follow-Up
More than 40 genetic risk variants for type 2 diabetes have been validated. We aimed to test whether a genetic risk score associates with the incidence of type 2 diabetes and with 5-year changes in glycemic traits and whether the effects were modulated by changes in BMI and lifestyle. The Inter99 study population was genotyped for 46 variants, and a genetic risk score was constructed. During a ...
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تاریخ انتشار 2013